Friday, March 28, 2008

ARE WE REALLY THIS ILL?

CHRISTOPHER LANE, NY SUN America has reached a point where almost half its population is described as being in some way mentally ill, and nearly a quarter of its citizens - 67.5 million - have taken antidepressants. These statistics have sparked a widespread, sometimes rancorous debate about whether people are taking far more medication than is needed for problems that may not even be mental disorders. Studies indicate that 40% of all patients fall short of the diagnoses that doctors and psychiatrists give them, yet 200 million prescriptions are written annually in America to treat depression and anxiety. Those who defend such widespread use of prescription drugs insist that a significant part of the population is under-treated and, by inference, under-medicated. Those opposed to such rampant use of drugs note that diagnostic rates for bipolar disorder, in particular, have skyrocketed by 4,000% and that overmedication is impossible without over-diagnosis.

To help settle this long-standing dispute, I studied why the number of recognized psychiatric disorders has ballooned so dramatically in recent decades. In 1980, the Diagnostic and Statistical Manual of Mental Disorders added 112 new mental disorders to its third edition, DSM-III. Fifty-eight more disorders appeared in the revised third edition in 1987 and fourth edition in 1994.

With over a million copies in print, the manual is known as the bible of American psychiatry; certainly it is an invoked chapter and verse in schools, prisons, courts, and by mental-health professionals around the world. The addition of even one new diagnostic code has serious practical consequences. What, then, was the rationale for adding so many in 1980?

After several requests to the American Psychiatric Association, I was granted complete access to the hundreds of unpublished memos, letters, and even votes from the period between 1973 and 1979, when the DSM-III task force debated each new and existing disorder. Some of the work was meticulous and commendable. But the overall approval process was more capricious than scientific.

DSM-III grew out of meetings that many participants described as chaotic. One observer later remarked that the small amount of research drawn upon was "really a hodgepodge - scattered, inconsistent, and ambiguous." The interest and expertise of the task force was limited to one branch of psychiatry: neuropsychiatry. That group met for four years before it occurred to members that such one-sidedness might result in bias.

Incredibly, the lists of symptoms for some disorders were knocked out in minutes. The field studies used to justify their inclusion sometimes involved a single patient evaluated by the person advocating the new disease. Experts pressed for the inclusion of illnesses as questionable as "chronic undifferentiated unhappiness disorder" and "chronic complaint disorder," whose traits included moaning about taxes, the weather, and even sports results.

Social phobia, later dubbed "social anxiety disorder," was one of seven new anxiety disorders created in 1980. At first it struck me as a serious condition. By the 1990s experts were calling it "the disorder of the decade," insisting that as many as one in five Americans suffers from it. Yet the complete story turned out to be rather more complicated. For starters, the specialist who in the 1960s originally recognized social anxiety - London-based Isaac Marks, a renowned expert on fear and panic - strongly resisted its inclusion in DSM-III as a separate disease category. The list of common behaviors associated with the disorder gave him pause: fear of eating alone in restaurants, avoidance of public toilets, and concern about trembling hands. By the time a revised task force added dislike of public speaking in 1987, the disorder seemed sufficiently elastic to include virtually everyone on the planet. . .

Over-medication would affect fewer Americans if we could rein in such clear examples of over-diagnosis. We would have to set the thresholds for psychiatric diagnosis a lot higher, resurrecting the distinction between chronic illness and mild suffering. But there is fierce resistance to this by those who say they are fighting grave mental disorders, for which medication is the only viable treatment. Failure to reform psychiatry will be disastrous for public health. Consider that apathy, excessive shopping, and overuse of the Internet are all serious contenders for inclusion in the next edition of the DSM, due to appear in 2012. If the history of psychiatry is any guide, a new class of medication will soon be touted to treat them. Sanity must prevail: if everyone is mentally ill, then no one is.

Mr. Lane, a professor of English at Northwestern University, is the author of "Shyness: How Normal Behavior Became a Sickness."

10 Comments:

At March 28, 2008 12:12 PM, Blogger xilii said...

Almost half the population may indeed be mentally ill. One of those halves voted for Bush (or Kerry) last time.

 
At March 28, 2008 4:30 PM, Anonymous "We Don't Torture" - Yeah, right! said...

Indeed, the psychosis of the public mirrors that in the White (man's) House.

 
At March 29, 2008 2:32 AM, Anonymous Anonymous said...

You don't have to be crazy to live here, but it helps.

 
At March 30, 2008 10:09 PM, Blogger Louis said...

I am inclined to discount - if not to dismiss - articles like this, since I worked as a psychiatric social worker for several years, and I have had occasion to work on regular hospital psychiatric wards.

As far as I can tell from former professional experience and my current reading of cultural trends, there is no doubt that American civilization is far more pathogenic in the year 2008 than it was even in the 1950s (when hundreds of millions of tranquilizers were sold) and the 1960s (when anti-depressants came into general use).

It is true, however, that we in the west have symptomatic medicine whose basic precept appears to be "get rid of the symptoms." The pill industry of the pharaceutical companies plays to this non-holistic approach to restoring people to health. We are certainly an overmedicated population, and not only in relaton to psychiatric medications. It's bad cultural design when pharmaceutical companies hawk their powerful drugs - whose ultimate effects are unknown - on television, and when non-specialist M.D. who have no formal training in psychopharmahology are allowed to prescribe these powerful drugs, even to very young people.

I date the current mania for psychoactive pills - and for DSM-IV clinical pigeonholes to fit them, from the late 1980s and the very successful introduction of the first SSRI, fluoxetine (Prozac) which gave tens of thousands of people who suffered from disabling depression not only emotional relief, but the ability to live a normal life. Anti-psychotic drugs like Zyprexa have enabled many severely incapacitated people diagnosed as schizophrenic to get into touch with reality and become near-normal again.

All these drugs have unwanted side-effects (I doubt that the side-effects are so drastic as to be the sole cause behind recent rampage killings though - but I'm not sure.) But up until 20 years ago, the anti-depressants and anti-psychotics that worked did with noticeable and drastic side-effects. Powerful example: tardive dyskinesia as irreversible harm done to patients kept on high doses of anti-psychotics like chorpromazine (thorazine and its related drugs).

The action of all important psychoactive drugs is unknown, and will remain so for another 50 to 100 years at the current rate at which brain science is advancing, even considering the help it is getting from recent technological advances in experimental apparatus, like finely controlled brain scans which have been introduced in the last two decades. I say this because I've been reading and hearing on the radio and watching on t.v. the "marvelous" discoveries of brain scientists for decades and yet they still have not come up with an conclusive discoveries which would convert into real clinical or other applied-scientific results.)

Finally, a quarter century ago it was noticed that we are an over-lawyered society. Back then we became, with the possible exception of one or two other nations, the country with the highest number of attorneys per capita of any culture on earth.

It would have been unusual even in the early 1970s to find full-page display ads in a local phone directory for tort lawyers who make an industry suing for money settlements. Now, such ads are a major source for ad revenues for such directories.

But try this: take a yellow pages and see if you can find an ad for a doctor - one who is not a cosmetic or eye surgeon - which is as large as the largest ads for the tort or criminal lawyers. If you do, very likely it won't be for a psychiatrist or a psychopharmacologist or a psychiatric treatment group. The field is among the most underpaid and - today - the least prestigious in medicine - because psychiatry doesn't involve invasive action (e.g. surgery, the most glamorous specialty) by an M.D.

The point here is that while people may be encouraged to seek out a psychiatric or psychopharmacological specialist in times of distress by a friend, or by a regular doctor's referral, or by pharmaceutical commercial they see on television, they won't likely be propagandized into doing so by such specialists themselves, as in the case of a lawyer you might hire to gain a financial settlement in a tort lawsuit.

It seems to me also that there is still a strong stigma of being a weakling or a "loser" (the worst American failing) which still deters people from seeking help for depression, severe anxiety or any other condition covered by DSM IV, or by such seemingly trivial diagnostic tags as "body dysmorphic disorder" or "agoraphobia" - conditions which can not only make people feel so horrible that they may debilitated (if not disabled) and may want to seek a healer's help. I honestly don't think that most people seek out such help, in other words, because they are hypochondriacs seeking mollycoddling, as this and other articles seem to imply.

 
At March 31, 2008 10:22 PM, Anonymous Anonymous said...

This is not true. Much of the action of modern psychoactive drugs IS known, but is also VERY complex. Each drug has a different action. Various SSRIs affect different combinations of serotonin receptors. MAOIs inhibit the breakdown of neurotransmitters such as serotonin and dopamine. Antipsychotics such as Zyprexa work on combinations of neurotransmitters. Your statement should read: action of all important psychoactive drugs is not FULLY known.

One seldom mentioned fact about SSRI antidepressants like Prozac and Zoloft is that they slow the mind's brain wave rate. Brain waves are the average firing rate of the brain's neurons, and slow brain waves, below a certain threshold, correspond to being asleep. Many long-term SSRI patients, particularly those on high SSRI doses, are literally SLEEPWALKING. When the mind's brain waves fall below a certain threshold, the brain's judgment center is bypassed. At that point, irrational impulses suicidal tendencies and "rampage killings" become more likely in patients taking SSRIs.

SSRIs are no longer recommended for most people under 18 ("children"), primarily due to increased risk of suicide. Children do not yet have the fully-developed judgment capabilities adults have, and are thus more prone to suicide due to brain waves slowed down by SSRIs. Many people also require increasing doses of SSRIs for the antidepressant affect to work. At some point, the antidepressant affect may no longer be working, resulting in a depressed patient who is literally sleepwalking, and you have a potential suicide case waiting to happen.

 
At March 31, 2008 10:23 PM, Anonymous Anonymous said...

action of all important psychoactive drugs is unknown

This is not true. Much of the action of modern psychoactive drugs IS known, but is also VERY complex. Each drug has a different action. Various SSRIs affect different combinations of serotonin receptors. MAOIs inhibit the breakdown of neurotransmitters such as serotonin and dopamine. Antipsychotics such as Zyprexa work on combinations of neurotransmitters. Your statement should read: action of all important psychoactive drugs is not FULLY known.

One seldom mentioned fact about SSRI antidepressants like Prozac and Zoloft is that they slow the mind's brain wave rate. Brain waves are the average firing rate of the brain's neurons, and slow brain waves, below a certain threshold, correspond to being asleep. Many long-term SSRI patients, particularly those on high SSRI doses, are literally SLEEPWALKING. When the mind's brain waves fall below a certain threshold, the brain's judgment center is bypassed. At that point, irrational impulses suicidal tendencies and "rampage killings" become more likely in patients taking SSRIs.

SSRIs are no longer recommended for most people under 18 ("children"), primarily due to increased risk of suicide. Children do not yet have the fully-developed judgment capabilities adults have, and are thus more prone to suicide due to brain waves slowed down by SSRIs. Many people also require increasing doses of SSRIs for the antidepressant affect to work. At some point, the antidepressant affect may no longer be working, resulting in a depressed patient who is literally sleepwalking, and you have a potential suicide case waiting to happen.

 
At April 1, 2008 3:28 PM, Blogger Louis said...

To Anonymous - When I wrote that "the action of all important psychoactive drugs is unknown" - I should have written "is not fully known" - for the sake of clarity.

The interactions you speak of are inferred interactions - the scientific literature associated with such drugs uses tentative language - as it ought to do - stating that (for example) fluoxetine ("Prozac") "is thought to act" upon serotonin levels in such-and-such a way - inhibiting its reuptake, etc.

What happens when this is transmuted into news reports or into political language is that the tentativeness necessary for scientific rigor "gets lost" - and we read that fluoxetine "acts to inhibit the reuptake of serotonin" - as if what had happened has been observed to happen, as a "covariation of observables in a system" - as if the changes had been observed in real time with rigorously set-up scientific parameters in an experiment.

There are many more neurotransmitters - "brain hormones" - in the brain than could possibly be observed in real time with the current state of the technologies which are increasingly making such observations possible.

By the 1960s it was becoming obvious to many researchers that several of the brain's chemicallly identifiable hormones were probably involved in psychiatrically diagnosable disorders. In Sweden, about thirty years ago, a psychiatrist, Dr. Marie Asberg, did an unusual experiment: spinal taps on people who had committed suicide. These tests won her credit for discovering that severe depression is slosely associated in a way that almost conclusively showed that there was a cause-effect relationship between low serotonin levels and severe depression. Drugs were tested which increased serotonin levels by inhibiting its reuptake. Fluoxetine proved to be the best and was introduced experimentally with great success in Europe in the late 1970s, almost a decade before it became available in the U.S.

But even so, the fluoxetine-serotonin relationship has not be demonstrated conclusively. It is inferential "extrapolation" from observables, at best. As the literature would put it, "its exact mechanism is unknown." This is also so with other powerfully effective psychoactive drugs.

And so it will be - and that is true of all psychoactive drugs - until scientists are able to obeserve the "mechanism" - the changes caused by fluoxetine - in real time - much in the way that medical doctors can see in real time the beneficial effect that surgically repairing a faulty heart valve has on blood circulation.

You state that people on "high SSRI doses are sleepwalking." That's the first I've read or heard of this. There may be an element of truth here in that toward the end of the 1990s, doctors were finding that patients who were prescribed very high doses of fluoxetine were not responding well and some were losing the therapuetic response all together. At that time, doses of 100 milligrams a day were acceptable. Now the typical dose is much lower.

Bear in mind too what I wrote above: there are many unqualified people who have medical degrees who've been able to get themselves certified by state medical boards in the U.S. who are prescribing these powerful drugs. Also, pharmaceutical companies should be stopped legally from flacking their drugs as "happiness-makers" on the tube and of course, they should be stopped from their ongoing campaign to money-corrupt the medical profession.

It's absurd and dangerous to tell a person who may be severely depressed - of suffering from any other life-threatening or debilitating psychiatric illness - that psychoactive drugs are inherently toxic - or will invariably turn a person into a sleepwalking zombie inclined to become suicidal or go on a rampage of murderous behavior. I know from intimate personal contacts of two cases where people have been simmilarly "advised" in which both committed suicide - needlesssly - in one case, the "caring" relatives sent a severely depressed woman to a naturopathic quack doctor in Texas instead of to a clinic at a major local New York City university teaching hospital I had recommended. This woman then killed herself - needlessly. She threw herself off of the roof of a parking garage of a hospital in Hackensack New Jersey where she had been treated for the autoimune disease which had brought on the depression.

 
At April 1, 2008 6:16 PM, Anonymous Anonymous said...

Actually, the most detailed research on SSRIs has studied the specific serotonin receptor sites (5-HT1A, 5-HT1B, etc.) specific SSRIs act on. It's available in literature from Harvard, and found in highly technical studies, but as you stated, highly technical aspects are omitted in news reports and more easily accessible political language.

The action of all important psychoactive drugs is not fully known, and is also highly complex. You correctly point out the brain operates with many different neurotransmitters, hormones, ad amino acids. I did not state all SSRI patient are "sleepwalking", but studies exist showing many on long term therapy, and/or high doses do exhibit slow brain wave patterns associated with being asleep. Obviously not all of the people in such a condition commit harmful actions, just as an unmedicated person who is sleepwalking is seldom dangerous. Google individual SSRIs with the phrase "brain wave" for more information. It helps to read up on the basics of brain waves first.

There are two things that can be done to more effectively treat people when prescribing psychoactive drugs. One would be regularly monitoring brain wave activity for unhealthy levels. The second would be to make use of inexpensive neurotransmitter tests, which test levels in urine and saliva. One such company is NeuroScience, Inc.

Again, as you said, unqualified people with M.D.s can prescribe these powerful medicines. Biochemically-based depression may be a result of low serotonin, low dopamine, low thyroid activity, or other hormonal imbalances, and in some cases, combinations of such imbalances. Testing neurotransmitter and hormone levels before prescribing drugs takes much of the guesswork out of the picture, and helps physicians select the most appropriate psychoactive drug, if needed.

Consider the case of a depressed person where the root imbalance is low dopamine. Prescription SSRIs do not affect dopamine levels, but a drug like Wellbutrin does. A simple neurotransmitter screening test would simplify the selection of th right medicine to target the specific neurotransmitter, rather than wit weeks or months on the wrong medicine waiting to see if a patient responds to it.

Sadly, depression can end up in suicide, regardless of whether one is being treated at a well-known clinic or university hospital or not. And there are nutritional therapies that have undergone scientific testing as rigorous, or even more rigorous, than big pharma's prescription happy pills. One such branch of medicine is called orthomolecular medicine. Not all naturopathic and nutritional therapies are worthless. There are quack doctors in both the naturopathic and licensed medical fields.

 
At April 1, 2008 7:50 PM, Blogger Louis said...

Anonymous - I can see that we're much more in agreement than I thought. And thanks for the Google suggestion. I'll look those findings up.

Studies are all well and good - I'm not terribly impressed by a Harvard provenance here though. The cruel fact is that cognitive psychology and "evolutionary psychology" and other pseudo-scientific disciplines which have a cobra-like hold on the relevant departments of that great university and others, are setting back other disciplines besides psychology - and I include brain science among the disciplines which are victims.

Harvard gave us the brilliant psychiatrist John E. Mack, who wrote a very impressive biography of T.E. Lawrence - but then became preoccupied with alien abductions. Remember that the sainted Timothy Leary - who actively encouraged an entire generation to dose themselves heavily with hallucinogenic drugs (drugs which would be harshly criticized, one assumes, by many progressives if they had the sanction of the pharmaceutical companies and the medical profession) was a Harvard lecturer in its psychology department for four years. Neither am I impressed much with brainwave studies per se - such studies have been around for 30 years and have accomplished little. We are in the greatest era of junk science in relation to people ever since the possibility of a scientific psychology was demonstrated in the late 19th century.

Any such studies would, I think, be valueless unless the observations obtained from them were accompanied by, and correlated with, a carefully recordedl clinical assessment of the relevant subject/patient's affect and behavior at the time of the study. (If the waveform suggests that the person is in the very low state of arousal and responding we customarily call "sleep," does the person appear drowsy? Does the person describe himself or herself as feeling sleepy or so drowsy as to feel that he or she has trouble not "dropping off to sleep." True, people's reports on their privately observable states are notoriously unrelable, but they are still relevant here. But again, I'll take a serious look at those study findings and thanks for mentioning them.

So far as brain hormones are concerned, surely you are aware that they interact with each other in ways so complex they could scarcely be said to be completely known in all their effects. Single causation rarely applies as often as we would like in the field of biology, even with organisms far "lower" than humans on the evolutionary scale.

I can't dispute what you say about naturopathic treatments being worthless. But I would if anyone maintained that they worked in ways described the kookily anti-scientific pseudo-explanatory theorizing that underlies naturopathy. Likewise, chiropractic - one can concede that some spinal manipulation therapies urged by chiropractors work - but not for the theoretical reasons - spinal "subluxations" and all the othe chiropractic pre-scientific chiropractic bibble-babble.

There are plenty of examples of this in the history of medical science. For the centuries, the "doctrine of signatures" "explained" that willow bark was an effective remedy against aches and pains because willow trees flourished in damp climates, and therefore had the power of counteracting certain " humours" which cause people to develop these complaints.

Only in the 19th century was it demonstrated (not "proved" - nothing scientific can be "proved" in the strict sense of that word) that salicin, a substance in willow bark similar to common aspirin, was the "potent thing" about willow bark.

In a hundred years from now - if enough civilized life survives - we'll have true explanations of the action of psychotropic drugs - not just "theories" or interestingly suggestive studies.

 
At April 1, 2008 9:44 PM, Anonymous Anonymous said...

Actually, drowsiness and excessive yawning are commonly reported side-effects of just about all the SSRIs. That is not to say the drowsiness side-effect is solely a function of slowed brain wave states: other biochemical factors are likely involved.

Of course brain biochemistry and physiology is almost infinitely more complex than the simplified descriptions of how most psychoactive drugs work, or for that matter, how naturopathic remedies claim to work.

Just as neurotransmitter levels can be measured, brain waves are an easily monitored, easily interpreted measurement of overall brain functioning. Any true explanation of the action of psychotropic drugs needs to incorporate all the scientific methods available to reach such understanding.

 

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